Care2 Healthy Living
New Research May Help 'Turn Off' Celiac Disease
8
New Research May Help ‘Turn Off’ Celiac Disease
8
tweet
0
0
email
24
By: Jordyn Cormier
March 5, 2018
About Jordyn
In America, millions of people suffer from Celiac disease, a chronic condition in which the gluten protein causes an inflammatory reaction in the small intestine. It can cause all sorts of unpleasantries, from diarrhea, flatulence and abdominal pain to irritability, anemia and more. And the only treatment is to completely avoid gluten for the rest of one’s life. But that life sentence might have a chance at getting a scientific commutation.
Love This? Never Miss Another Story.
Scientists have discovered an intestinal protein that supports the metabolization of gluten in the body, and it has an on/off switch. Currently, scientists have a relatively poor understanding of this intestinal protein, known as TG2, but they know one thing: it can be turned on and off with the help of a certain enzyme. A healthy human small intestine contains a lot of TG2, but it is generally all inactive, which has led scientists to wonder What turns TG2 off? Would deactivating TG2 allow Celiacs to consume wheat and follow a less restrictive diet?
When a person with Celiac disease consumes gluten, the body launches an intensive immune assault against the protein. This immune response hits the fan when gluten is modified by the TG2 protein in the gut. The body begins attacking with full force, but what if TG2 didn’t turn on? Could a person with Celiac theoretically consume bread, pasta and pizza again?
It seems that TG2 is activated when its disulfide bond is broken, and scientists have discovered an enzyme that does this. It’s called ERp57, and it is mainly responsible for folding proteins inside of a cell. Why it drifts outside the cell in those with Celiac to activate TG2 and cause the body to attack gluten is still poorly understood. The specific chemistry behind the reaction is actually very unique and will require a lot more research before scientists can claim a solid understanding of the process.
Research is currently only being conducted on cells outside the body. Human research/treatment is still far off in the future. But developing therapies that could switch off the TG2 protein presents a promising avenue of treatment for millions of Celiac sufferers everywhere. There is currently little to be done for Celiac sufferers, other than a fervent abstinence from gluten. For those who feel bound by their restrictive diet, this is heartening news for sure.
What do you think? If you have Celiac, would you take a drug if it meant a significantly less restrictive diet for the rest of your life? Share your thoughts below.
Related on Care2:
Why You Shouldn’t Sleep in Bed with Your Dog
6 Hacks to Make Vegan Traveling A Lot Easier
Cutting Out Fruit Won’t Help You Lose Weight
GREAT STORY, RIGHT?
Share it with your friends
8
tweet
0
0
email
CONNECT WITH US
Facebook 1.1 million followers
Twitter 560,000 followers
Pinterest 30,000 followers
Email Newsletter
EMAIL THE EDITORS
You Might Also Like
South Carolina mom files police report against student who shared her daughter’s racist Snapchat post South Carolina mom files police report against student who shared her daughter’s racist Snapchat post theGrio
Dynamic Stretches For Runners | Redefining Strength Dynamic Stretches For Runners | Redefining Strength @ManBicep
How to Tell if Your Nail Polish is Toxic How to Tell if Your Nail Polish is Toxic
4 Foods That Age You Faster 4 Foods That Age You Faster
24 Cheesy Recipes So Good You’d Never Guess They Are Dairy-Free 24 Cheesy Recipes So Good You’d Never Guess They Are Dairy-Free
Slaughterhouse Work Is So Horrible, Canada Can’t Find Anyone to Do It Slaughterhouse Work Is So Horrible, Canada Can’t Find Anyone to Do It
Recommended by
24 comments
Past Member
Past Member 7 minutes ago
i am happy and i want to share that My PREVIOUS month's on-line financial gain is $6500. i am currently ready to fulfill my dreams simply and reside home with my family additionally. I work just for two hours on a daily basis. everybody will use this home profit system by this link.
......................... http://www.homework5.com
SEND
Elizabeth H
Elizabeth H12 minutes ago
Any thing that can be done to help should be applauded.
SEND
Cathy B
Cathy B17 minutes ago
Thank you for sharing.
SEND
RK R
RK R19 minutes ago
.0053 of the US population has Celiac Disease.
SEND
Ian C
Ian C42 minutes ago
:LO
SEND
Sheila D
Sheila Dabout an hour ago
I don't have Celiac, but I am gluten intolerant. This would be a wonderful help to me and all those I know who have Celiac. Thanks for sharing.
SEND
Roxana Saez
Roxana S2 hours ago
TYFS
SEND
Long S
Long S3 hours ago
There is currently little to be done for Celiac sufferers.
replica louis vuitton
SEND
Sherry Kohn
Sherry K4 hours ago
Many thanks to you !
SEND
Chrissie R
Chrissie R4 hours ago
Good news for those people with celiac disease.
SEND
view all 24 comments
TOP STORIES
1
16 Natural Ways to Help Depression
2
Why You Shouldn't Sleep in Bed with Your Dog
3
4 Ways You Disempower Yourself on a Daily Basis
4
4 Questions to Ask Yourself Before Going Plant-Based
5
A Nutritionist's Best Tips for Jumpstarting Your Immune System
ads keep care2 free
learn more ▸
add this widget to your site
ads keep care2 free
learn more ▸
COMMUNITY SUCCESS!
Victory! UK to Ban Wild Animals in Circuses
In another major victory for animals used in entertainment, England has pledged to ban the use...
more
8
tweet
0
0
Care2 Home
About Us
Contact Us
advertising
Copyright © 2018 Care2.com, inc. and its licensors. All rights reserved
site feedback
site feedback
log in / Join
Start A Petition
Sign Petition
CARE2 Home
healthy living
Food + Recipes
Health
Love + Sex
Green
News
Crafts
Ecards
Brands for Good
Nature
Pets
Spirit
Home
Life
Family
Beauty
causes & news
Success Stories
butterfly rewards
New to Care2? Start Here.
About Us
Care2 Team Blog
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment