Dr. Mercola: Rhodiola Reduces Fatigue

Mercola.com
Rhodiola Reduces Fatigue
Written by Dr. Joseph Mercola Fact Checked

    March 11, 2019

rhodiola reduces fatigue
Story at-a-glance -

    Rhodiola is an ancient, flowering plant with a wide variety of related uses, from reducing depression, anxiety and physical, chemical and environmental stress to elevating your mood
    Mechanisms for rhodiola’s mood-improving effectiveness stem in part from its ability to enhance your brain’s serotonin levels by optimizing its passage through the blood-brain barrier
    Rhodiola is known as a nootropic, or a substance that enhances brain function, as well as an adaptogen, meaning they can provide different effects depending on what your body needs
    Salidroside, rosavin and tyrosol are three of more than 140 different and powerful organic compounds related to health that have been identified in rhodiola, and three of the most important

Scientists around the world have been keenly studying the attributes of a root plant known as rhodiola, which is a tough perennial that produces beautiful, chrysanthemum-like flowers. Beyond its attractive appearance, though, rhodiola has a number of highly valuable qualities for health.

Rhodiola thrives in cold mountainous regions and barren sea cliffs such as those in Northern Asia, Europe and North America. Closely related species also used in traditional medicine include Rhodiola imbricata, Rhodiola algida and Rhodiola crenulata.

Because its history harkens as far back as the Vikings, rhodiola has several different monikers. Besides the scientific name Rhodiola rosea, it's also known as golden root, rose root, king's crown and hóng jǐng tiān, depending on where it's found.

For millennia, people familiar with the plant used its extracts to improve strength and virility. For instance, Siberian brides were given rhodiola sprigs to increase their physical endurance to face long, sub-zero winters, fend off anxiety and depression, and increase fertility.1

A renowned Greek text known as De Materia Medica, written in 77 A.D., describes numerous medicinal properties from the plant's stem. According to Swedish Medical Center,2 rhodiola was long ago integrated into the traditional medicines of Sweden, Norway, Iceland and Russia.

Recent history supports many of even the most ancient claims. Introduced to a body that's flagging due to prolonged or higher-than-normal stress, rhodiola has been proven to relieve both physical and mental fatigue, soothe frazzled nerves and even improve the ability to concentrate.3
Wide-Ranging Benefits of Rhodiola Impact Your Body and Mind

Rhodiola boasts an extensive list of vitality-boosting abilities found in the stem, roots and leaves of the plant, such as boosting your immunity from disease, positively impacting brain, organ, nerve, sexual4 and neurological functions, and helping to prevent damage to all of the above.5,6,7,8,9 Some studies suggest it can even increase your lifespan.10 One study notes:

    "Studies on isolated organs, tissues, cells and enzymes have revealed that Rhodiola preparations exhibit adaptogenic effect including, neuroprotective, cardioprotective, antifatigue, antidepressive, anxiolytic, nootropic, life-span increasing effects and CNS (central nervous system) stimulating activity.

    A number of clinical trials demonstrate that repeated administration of R. rosea extract SHR-5 exerts an antifatigue effect that increases mental performance (particularly the ability to concentrate in healthy subjects), and reduces burnout in patients with fatigue syndrome.

    Encouraging results exist for the use of Rhodiola in mild to moderate depression, and generalized anxiety. Several mechanisms of action possibly contributing to the clinical effect have been identified for Rhodiola extracts."11

One way the compounds in rhodiola are beneficial is that they support your body's ability to stave off another type of stress: oxidative. It also helps fight infection and burn energy, while simultaneously helping to decrease inflammation, increase energy, prevent fat buildup, protect your heart and lungs, reduce pain and improve your mood.

The latter benefit explains why rhodiola is known as a nootropic, described as a substance that enhances brain function. Rhodiola has its own benefits in this regard, as it stimulates brain activity and has been found to be directly responsible for activating four important neurotransmitters:

    Norepinephrine
    Serotonin
    Dopamine
    Acetylcholine

Each of these is significant as depression is strongly linked to low dopamine. Studies note that working together, these neurotransmitters are important for memory, concentration and learning.12 Rhodiola also improves wakefulness and reduces both physical and mental fatigue, as well as anxiety.

Further, rhodiola may be a possible safe alternative to SSRIs (selective serotonin reuptake inhibitor drugs)13 or antidepressants such as sertraline, also known as Zoloft.14
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The Powerful Benefits of the Rhodiola Compound Salidroside

Where do all these incredible benefits come from? The rose-like fragrance is due to the presence of geraniol essential oil, but more than 140 different and powerful organic compounds related to health have been identified in rhodiola. Three of the most important, noted for having adaptogenic properties (meaning they can provide different effects depending on what your body needs) are:

    Salidroside, also known as rhodioloside, considered by many experts to be the plant's most important bioactive molecule, and likely responsible for its protective and stimulant effects on the brain.15
    Rosavin, which has many of the same properties and mechanisms as salidroside, but requires a higher dose to produce the same effect.16
    Tyrosol, which is one of the antioxidant elements in rhodiola extracts, but while it may contribute to its benefits, it often goes unlabeled on commercial supplements.17

One study shows salidroside helps restore the balance between free radicals and antioxidants, and protects your brain against poor blood flow and subsequent stroke (aka ischemia).18

Due to its antibacterial strength, salidroside has also been used successfully to treat acne. While standard acne treatments can trigger antibiotic resistance and even worse problems, salidroside can get rid of the thin, slimy layer of bacterial cells known as biofilm that is difficult to eradicate.19

Its antioxidant activity may help fight aging, although the mechanisms are not well-studied in humans. It is well-known, though, that high oxidative stress underlies many chronic diseases and age-related health problems.20
Pathways and Mechanisms Connected to Salidroside

How does it manage all these benefits? It turns out that salidroside is responsible for the activation of several crucial pathways to exert many of the rhodiola plant's most important benefits.

One is the Nrf2 pathway, a genetic pathway that turns on protective genes, increases antioxidant proteins and protects cells, leading the authors of one study to posit that salidroside may be useful in treating ischemic stroke.21 Rhodiola also activates AMPK, which boosts antioxidant protein production, prevents insulin resistance, reduces inflammation, controls your blood sugar and prevents fat buildup in your liver.22,23

Cytokines are signaling molecules secreted by certain immune system cells, which affect other cells, including those in relation to inflammation and immunity. Referred to as the "bad guys" that are high in chronic inflammation, in acute infections, the right balance of cytokines are needed to mount a successful attack. However, Th1 dominance may occur for people with chronic inflammation and/or autoimmune diseases when this pathway is over-activated.

Certain inflammatory cytokines may be selectively decreased when rhodiola extracts are applied, such as when one study showed that mice injected with E. coli, then given a large dose of rhodiola extract, experienced "significantly" lower kidney and brain inflammation.24
Rhodiola's Effects on Stress

Here's one way rhodiola can be worth its weight in gold for the way it boosts your energy and allows you to thrive even in the midst of stress:

    "Stress may allow the body more energy at the moment, but this is not a sustainable energy solution. After prolonged periods of stress, the very processes and neurochemicals needed for efficient energy are compromised.

    For example, dopamine and serotonin keep the mind focused and positive for hours on end and fight off tension and impulsiveness. Stress robs the body of these neurotransmitters essential to extended thought processing.

    It also interferes with the thyroid and its stimulating hormones and decreases the body's metabolism. Try and be productive without the body's energy assimilation process in proper function — you won't last long."25

Salidroside also acts on the HPA axis — the hypothalamus, pituitary gland and adrenal gland — comprising a system of glands that control many of the body's stress responses — such as the release of cortisol, another study notes.26

Salidroside is an example of an adaptogen that facilitates the expression of Hsp70, a "heat-shock protein" that helps cells adapt to repeated exposure to the same stressors.27 It may also increase tolerance to both emotional and physical stress, decrease Hsp70 expression in stomach cancer cells, specifically related to its effect on colon cancer cells, as the extract also:

    "Inhibits cell proliferation and induces cell apoptosis in various cells and cell lines, including human urinary bladder cancer cell lines, breast cancer cell lines, colorectal cancer cells, gastric cancer cells, glioma cells, lung cancer cells, and sarcoma."28

For example, osteoporosis, a disease that causes bone density to decrease, is partially caused by oxidative stress. Salidroside's antioxidant effects may help prevent osteoporosis and maintain bone health later in life. Salidroside's antioxidant effects may even augment future bone health.29
Rhodiola Caveats, Disclosures and Supplementation

Use caution in combining rhodiola with certain prescription medications. Monoamine oxidase inhibitors shouldn't be combined with substances that increase dopamine or norepinephrine.30

Don't take rhodiola with SSRIs, drugs for high blood pressure, diabetes CYP2C9 substrates, phenytoin and warfarin or antidepressants without the advice of your physician. At least one study has found that rhodiola may reduce chronic fatigue symptoms at doses of 400 milligrams (mg) day, with few or no side effects.31

Rhodiola rosea supplements come in the form of caplets, tea or liquid extracts, but high-quality extracts should contain at least 3 percent rosavins and 1 percent salidroside. Other species of rhodiola, such as R. crenulata, might have much higher concentrations of salidrosides.32

+ Sources and References
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